解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Manufactured nanomaterials (MNMs) selected from a library of over 120 different MNMs with varied compositions, sizes, and surface coatings were tested by four different laboratories for toxicity by high-throughput/-content (HT/C) techniques. The selected particles comprise 14 MNMs composed of CeO2, Ag, TiO2, ZnO and S...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2106-7
更新日期:2018-02-01 00:00:00
abstract::Acetaminophen (APAP) overdose is the leading cause of acute liver failure. Yet the mechanisms underlying adaptive tolerance toward APAP-induced liver injury are not fully understood. To better understand molecular mechanisms contributing to adaptive tolerance to APAP is an underpinning foundation for APAP-related prec...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2090-y
更新日期:2018-02-01 00:00:00
abstract::The rodenticide tetramethylenedisulfotetramine (TETS) is a potent convulsant (lethal dose in humans 7-10 mg) that is listed as a possible threat agent by the United States Department of Homeland Security. TETS has previously been studied in vivo for toxicity and in vitro in binding assays, with the latter demonstratin...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2089-4
更新日期:2018-02-01 00:00:00
abstract::Skin sensitisation is the regulatory endpoint that has been at the centre of concerted efforts to replace animal testing in recent years, as demonstrated by the Organisation for Economic Co-operation and Development (OECD) adoption of five non-animal methods addressing mechanisms under the first three key events of th...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2097-4
更新日期:2018-02-01 00:00:00
abstract::In the recent years, the toxicity of certain divalent cations has been associated with the alteration of intracellular Ca2+ homeostasis. Among other mechanisms, these cations may affect the functionality of certain Ca2+-binding proteins and/or Ca2+ pumps. The plasma membrane calcium pump (PMCA) maintains Ca2+ homeosta...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2031-9
更新日期:2018-01-01 00:00:00
abstract::Although shorter chain homologues and other types of fluorinated chemicals are currently used as alternatives to long-chain perfluoroalkyl substances (PFASs), their safety information remains unclear and urgently needed. Here, the cytotoxicity of several fluorinated alternatives (i.e., 6:2 fluorotelomer carboxylic aci...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2055-1
更新日期:2018-01-01 00:00:00
abstract::A number of industrial chemicals and therapeutic agents cause liver tumors in rats and mice by activating the nuclear receptor peroxisome proliferator-activated receptor α (PPARα). The molecular and cellular events by which PPARα activators induce rodent hepatocarcinogenesis have been extensively studied elucidating a...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-017-2094-7
更新日期:2018-01-01 00:00:00
abstract::Exposure to high-dose benzene leads to the inhibition of erythroid differentiation. However, whether lower doses of benzene exposure resemble high-dose effects in erythroid differentiation, as well as the underlying mechanisms, remains largely unknown. To identify the microRNAs (miRNAs) specifically responsible for be...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2033-7
更新日期:2018-01-01 00:00:00
abstract::Certain bisphenols (BPs) have been regarded as endocrine-disrupting chemicals due to their structural similarities to bisphenol A (BPA), a well-known weak estrogenic chemical. However, very limited data are currently available on the relationship between estrogenic activity and the structure of BP analogs. Therefore, ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2011-0
更新日期:2017-12-01 00:00:00
abstract::Carbon tetrachloride-induced liver injury is a thoroughly studied model for regeneration and fibrosis in rodents. Nevertheless, its pattern of liver fibrosis is frequently misinterpreted as portal type. To clarify this, we show that collagen type IV+ "streets" and α-SMA+ cells accumulate pericentrally and extend to ne...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2040-8
更新日期:2017-11-01 00:00:00
abstract::Microsomal and soluble epoxide hydrolase (mEH and sEH) fulfill apparently distinct roles: Whereas mEH detoxifies xenobiotics, sEH hydrolyzes fatty acid (FA) signaling molecules and is thus implicated in a variety of physiological functions. These epoxy FAs comprise epoxyeicosatrienoic acids (EETs) and epoxy-octadeceno...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2060-4
更新日期:2017-11-01 00:00:00
abstract::Organotin compounds such as tributyltin (TBT) and triphenyltin can induce diabetes and insulin resistance. However, the development of diabetes caused by organotins and its underlying mechanisms remain unclear. In the present study, male KM mice were orally administered with TBT (0.5, 5, and 50 μg/kg) once every 3 day...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-1961-6
更新日期:2017-10-01 00:00:00
abstract::A set of biomedically relevant iron oxide nanoparticles with systematically modified polymer surfaces was investigated regarding their interaction with the first contact partners after systemic administration such as blood cells, blood proteins, and the endothelial blood vessels, to establish structure-activity relati...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-1968-z
更新日期:2017-10-01 00:00:00
abstract::Aluminum phosphide (AlP), one of the most commonly used pesticides worldwide, has been the leading cause of self-poisoning mortalities among many Asian countries. The heart is the main organ affected in AlP poisoning. Melatonin has been previously shown to be beneficial in reversing toxic changes in the heart. The pre...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-1998-6
更新日期:2017-09-01 00:00:00
abstract::Drug-induced liver injuries have been a major focus of current research in drug development, and are also one of the major reasons for the failure and withdrawal of drugs in development. Drug-induced liver injuries have been systematically recorded in many public databases, which have become valuable resources in this...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-017-2024-8
更新日期:2017-09-01 00:00:00
abstract::Drug-induced liver injury (DILI) continues to be a major source of clinical attrition, precautionary warnings, and post-market withdrawal of drugs. Accordingly, there is a need for more predictive tools to assess hepatotoxicity risk in drug discovery. Three-dimensional (3D) spheroid hepatic cultures have emerged as pr...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-017-2002-1
更新日期:2017-08-01 00:00:00
abstract::In this review, we introduce a new concept, precision toxicology: the mode of action of chemical- or drug-induced toxicity can be sensitively and specifically investigated by isolating a small group of cells or even a single cell with typical phenotype of interest followed by a single cell sequencing-based analysis. P...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-017-1971-4
更新日期:2017-07-01 00:00:00
abstract::Perfluorocarboxylic acids (PFCAs) including perfluorooctanoic acid (PFOA) are environmental pollutants showing high accumulation, thermochemical stability and hepatocarcinogenicity. Peroxisome proliferator-activated receptor α is suggested to mediate their toxicities, but the precise mechanism remains unclear. Previou...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-016-1888-3
更新日期:2017-06-01 00:00:00
abstract::Aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor, has been studied extensively in carcinogenesis through the genomic pathway. In recent years, AHR has also been reported to exert positive or negative effects on epithelial-mesenchymal transition (EMT), the crucial step in tumor malignant progres...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-016-1870-0
更新日期:2017-05-01 00:00:00
abstract::Human precision-cut liver slices (hPCLS) are a valuable ex vivo model that can be used in acute toxicity studies. However, a rapid decline in metabolic enzyme activity limits their use in studies that require a prolonged xenobiotic exposure. The aim of the study was to extend the viability and function of hPCLS to 5 d...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-016-1865-x
更新日期:2017-05-01 00:00:00
abstract::Pentachlorophenol (PCP) and Dichlorodiphenyltrichloroethane (DDT) are environmental contaminants found in human blood. Previous studies have shown that PCP and DDT inhibit the lytic function of highly purified human natural killer (NK) lymphocytes and decrease the expression of several surface proteins on NK cells. In...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-016-1829-1
更新日期:2017-04-01 00:00:00
abstract::Previously we reported that exposure of mouse and human mast cells to aryl hydrocarbon receptor (AhR) ligands resulted in reactive oxygen species (ROS)- and calcium (Ca2+)-dependent activation of mast cells in vitro and in vivo. However, the mechanisms through which the AhR-ligand axis mediates stress response, Ca2+ s...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-016-1861-1
更新日期:2017-04-01 00:00:00
abstract::Glucose is a major energy source for the entire body, while fructose metabolism occurs mainly in the liver. Fructose consumption has increased over the last decade globally and is suspected to contribute to the increased incidence of non-alcoholic fatty liver disease (NAFLD). NAFLD is a manifestation of metabolic synd...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-016-1892-7
更新日期:2017-04-01 00:00:00
abstract::Genistein and daidzein are the main isoflavones in soy. Their potential beneficial or adverse effects in males like the prevention of prostate cancer or the impact on reproductive functions are controversially discussed. Major determinants of their bioactivity are the absorption and biotransformation of isoflavones. I...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-016-1853-1
更新日期:2017-04-01 00:00:00
abstract::Current developmental neurotoxicity (DNT) testing in animals faces major limitations, such as high cost and time demands as well as uncertainties in their methodology, evaluation and regulation. Therefore, the use of human-based 3D in vitro systems in combination with high-content image analysis (HCA) might contribute...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-016-1852-2
更新日期:2017-04-01 00:00:00
abstract::The development of metabolically competent in vitro models is of utmost importance for predicting adverse drug reactions, thereby preventing attrition-related economical and clinical burdens. Using the antiretroviral drug nevirapine (NVP) as a model, this work aimed to validate rat hepatocyte 3D spheroid cultures as c...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-016-1792-x
更新日期:2017-03-01 00:00:00
abstract::Blooms of cyanobacteria have been documented throughout history, all over the world. Mass populations of these organisms typically present hazards to human health and are known for the production of a wide range of highly toxic metabolites-cyanotoxins, of which among the most common and most investigated are the micro...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-016-1921-6
更新日期:2017-02-01 00:00:00
abstract::Hydroxysteroid sulfotransferase 2B1b (SULT2B1b) sulfates cholesterol and oxysterols. Hepatic oval cells (HOCs), thought to be progenitor cells, can be triggered in chemically injured livers. The present study focused on the role of SULT2B1b in HOC proliferation after liver injury. Our experiments revealed that the exp...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-016-1693-z
更新日期:2017-01-01 00:00:00
abstract::The mycotoxins altertoxin I and II (ATX I and II) are secondary metabolites produced by Alternaria alternata fungi and may occur as food and feed contaminants, especially after long storage periods. Although the toxic potential of altertoxins has been previously investigated, little is known about the pathways that pl...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-016-1726-7
更新日期:2017-01-01 00:00:00
abstract::Perfluorooctanoic acid (PFOA) has been shown to cause hepatotoxicity and other toxicological effects. Though PPARα activation by PFOA in the liver has been well accepted as an important mechanism of PFOA-induced hepatotoxicity, several pieces of evidence have shown that the hepatotoxic effects of PFOA may not be fully...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-016-1675-1
更新日期:2017-01-01 00:00:00
abstract::Mercury exists in the environment in various forms, all of which pose a risk to human health. Despite guidelines regulating the industrial release of mercury into the environment, humans continue to be exposed regularly to various forms of this metal via inhalation or ingestion. Following exposure, mercuric ions are t...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-016-1803-y
更新日期:2017-01-01 00:00:00
abstract::Hexamoll® DINCH® (diisononyl-cyclohexane-1,2-dicarboxylate) is a new high molecular weight plasticizer and a non-aromatic phthalate substitute. In this follow-up study, we further investigated the extensive oxidative metabolism of Hexamoll® DINCH® after oral dosage of 50 mg to three male volunteers (0.552-0.606 mg/kg ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-016-1688-9
更新日期:2017-01-01 00:00:00
abstract::Chronic exposure to propiverine, a frequently prescribed pharmaceutical for treatment of overactive bladder and incontinence, provokes massive protein accumulation in the cytosol and nucleus of renal proximal tubule epithelial cells in rats. Previously, the accumulating protein was identified as D-amino acid oxidase (...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-016-1685-z
更新日期:2017-01-01 00:00:00
abstract::Nanoparticles (NP) have a tendency to agglomerate after dispersion in physiological media, which can be prevented by the addition of serum. This may however result in modification of the toxic potential of particles due to the formation of protein corona. Our study aimed to analyze the role of serum that is added to i...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-016-1673-3
更新日期:2017-01-01 00:00:00
abstract::The current test systems employed by pharmaceutical industry are poorly predictive for drug-induced liver injury (DILI). The 'MIP-DILI' project addresses this situation by the development of innovative preclinical test systems which are both mechanism-based and of physiological, pharmacological and pathological releva...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-016-1845-1
更新日期:2016-12-01 00:00:00
abstract::Mycotoxins are the most frequently occurring natural contaminants in human and animal diet. Among them, deoxynivalenol (DON), produced by Fusarium, is one of the most prevalent and thus represents an important health risk. Recent detection methods revealed new mycotoxins and new molecules derivated from the "native" m...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-016-1826-4
更新日期:2016-12-01 00:00:00
abstract::Nucleotide excision repair (NER) is a versatile pathway that removes helix-distorting DNA lesions from the genomes of organisms across the evolutionary scale, from bacteria to humans. The serial steps in NER involve recognition of lesions, adducts or structures that disrupt the DNA double helix, removal of a short oli...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-016-1820-x
更新日期:2016-11-01 00:00:00
abstract::The comet assay is a versatile, reliable, cost-efficient, and fast technique for detecting DNA damage and repair in any tissue. It is useable in almost any cell type and applicable to both eukaryotic and prokaryotic organisms. Instead of highlighting one of the numerous specific aspects of the comet assay, the present...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-016-1767-y
更新日期:2016-10-01 00:00:00
abstract::The implementation of the Chemical Weapon Convention (CWC), prohibiting the development, production, storage and use of chemical weapons by 192 nations and the ban of highly toxic OP pesticides, especially class I pesticides according to the WHO classification, by many countries constitutes a great success of the inte...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-016-1772-1
更新日期:2016-09-01 00:00:00
abstract::Neutrophils infiltrate tissues during inflammation, and when activated, they release β-glucuronidase. Since inflammation is associated with carcinogenesis, we investigated how extracellular β-glucuronidase changed the in vitro cellular response to the chemical carcinogen benzo(a)pyrene (B[a]P). For this we exposed hum...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1593-7
更新日期:2016-09-01 00:00:00